f-tree iPad / iPhone App is also available. f-tree

A novel automated questionnaire-based pedigree chart creation software


  • f-tree is a software application that automatically creates medical pedigree chart of a family by simply using the family's information, which is provided in the questionnaires.
  • Specialized knowledge of clinical genetics is not required to use the f-tree software.
  • f-tree is fully compliant with the international recommendations provided for standardized human pedigree nomenclature.
  • At present,f-tree proves to be the foremost tool, which is capable of creating the pedigree charts for genetic counseling.
  • The application of f-tree software is not only limited to the heredity clinics, but can also used in genome cohort studies that can easily handle large volume of data, and secondary education.
  • f-tree desktop version is available for both Windows and mac OS.
  • f-tree iOS version is available for iPad and iPhone.

    Adobe AIR must be installed to run f-tree desktop version

    Click the icon below to download from the HARMAN website.

    *From 2021, support for Adobe AIR has been transferred from Adobe to HARMAN, but you can still download it for free.

    Get Adobe AIR

    For mac users
    *Hardware with Apple silicon such as M1 cannot start f-tree at first. This is due to a known issue with HARMAN AIR. To avoid this, right-click the f-tree icon in the application folder in Finder, select [Get Info], and check the [Open using Rosetta] check box in the displayed dialog.

    Permission error


    Download Form

    f-tree users are requested to accept the terms of use before using the softwre for conference presentations, manuscript preparation, or commercial purposes.

    I agree to the following terms regarding the use of the family tree preparation software (f-tree) (hereafter referred to as “the Software”) that are released by the Iwate Tohoku Medical Megabank Organization, Iwate Medical University (hereafter referred to as “the Organization”).

    ・In principle,the Software shall be provided free of charge.

    ・It shall be verified that the computer used for operation complies with the usage conditions and validation required by the Software.

    ・The user shall bear complete responsibility for installing and using the Software. The Organization confirms that it will not bear liability for any or all the problems that the user might experience while installing or using the Software. The Organization also confirms that it will not bear liability for any dispute between the user and the third party (including but not limited to a dispute concerning copyright or other issue related to intellectual property right).

    ・If the Software is used to prepare a presentation for an academic organization, a published article, a book, or an entry in a company's pamphlet, the user shall provide the URL that is used to distribute the Software and an acknowledgement for its use.

    ・All the rights, such as copyright to the Software and copies of the Software, shall solely belong to the Organization.

    ・The Software shall not be used for any other purpose and shall not be distributed to a third party.

    ・The Software shall not be entirely or partly revised, modified, reverse engineered, compiled, or assembled.

    ・None of the part of the Software shall be copied, corrected, loaned, sold, distributed, or transferred. Additionally, copying without authorization is completely prohibited.

    ・The Software shall not be used for any commercial activity (rental, pseudo-rental, or sales to a third party).

    ・It must be confirmed that when the user is authorized to use the Software, this neither explicitly nor implicitly grants the user a guarantee of any kind.

    ・It shall be confirmed that the Software might be improved or modified without any prior notification.


    Please contact the following email address every time when researching,making a conference presentation, and presenting a paper with the software.

    Also, please quote the following literature when using the software for an academic paper.
    Tokutomi T, Fukushima A, Yamamoto K, Bansho Y, Hachiya T, Shimizu A. BMC Med Genet. 2017;18:71.

    How did you find out f-tree?

    Purpose of use





    "Ctrl + click to make multiple selections"

    Ver4.2.1: Conformed to the newest recommendation (Bennett et al. 2022)

    Ver4.1.0: Conformed to the previous recommendation (Bennett et al. 2008)


    Update information

    May 10, 2023
    v4.2.1 Conformed to the newest recommendation (Bennett et al. 2022)
    -Added cultural and social gender differences.
    -Disabled to set carrier.
    -Minor bug fixed.


    February 07, 2022
    v4.1.0 Conformed to the previous recommendation (Bennett et al. 2008)
    -The layout of the questionnaire window has been completely improved.
    -Added month input to age. Added day input to gestational age.
    -Delimiter for disease name can be selected.
    -Display an alert when you try to enter beyond the input range.
    -Minor bug fixed.


    June 11, 2021
    Set the gender default value to 'Unknown' when adding a new child.
    Minor bug fixed.


    Sep 14, 2020
    Improved security vulnerabilities.


    July 07, 2020
    Bug fixed.


    March 26, 2020
    Added a function to change the symbol size of individuals.


    December 10, 2019
    Adjusted vertical size. Making the relationship line a polygonal line and align the height of the symbols. Bug fixed.


    September 03, 2019
    Bug fixed.


    September 02, 2019
    Added HL7 import function of family-t. Added family-t CSV import function. French language support. Added a function to set the location and number of characters under an symbol. File extension changed. Bug fixed.


    Jun 11, 2018
    Bug fixed.


    April 12, 2018
    Bug fixed.


    January 29, 2018
    f-tree and f-treeGC integration.


    December 2, 2017
    GC v1.1.1


    November 10, 2017
    GC v1.1.0


    October 18, 2017
    GC v1.0.1


    May 17, 2017
    GC v1.0.0


    January 5, 2017


    Jun 26, 2015


    March 19, 2015



    ABOUT f-tree

    f-tree software has been mutually developed by the Clinical Genetics Department of Iwate Medical University and Holonic Systems Ltd.
    f-tree has a registered trademark (5777066) with a patent pending (2017-068503) in Japan.
    It will work on the Adobe AIR. We tested it on the operating systems,including MAC OS X and Windows 7 / 8.1 / 10.
    A video,explaining the usage of f-tree ver. 1.1.5, is made available on TOGO TV.
    Produced by Dr. H. Ono and Dr. H. Bono of Database Center.



    We exhibited f-tree at ICHG2016  13th International Congress of Human Genetics.
    The Book "Let's study the Clinical Genetics with f-tree; the Automated Pedigree Chart Creating Software." by the publisher CHUGAI-IGAKUSHA is now on sale.
    Let's study the Clinical Genetics with f-tree; the Automated Pedigree Chart Creating Software.





    Holonic Systems, Ltd. ("us", "we", or "our") operates the website and f-tree application (the "Service"). This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Service . We use your data to provide and improve the Service. By using the Service, you agree to the collection and use of information in accordance with this policy.
    1.Information Collection
    When registering for use, we ask that you enter personal information such as purpose of use, age, gender, region, occupation, etc. as a questionnaire. Also, when you make an inquiry, we ask you to enter personal information such as organization, name, and email address.
    2.purpose of use
    For the provision and operation of our services To answer inquiries from users (including verification of identity) To send e-mails about new features, updates, campaigns, etc. of the service you are using and other services provided by our company. For maintenance, important notices, etc. to contact you as needed To identify users who violate the terms of use or who intend to use the service for fraudulent or unreasonable purposes, and refuse to use the service. To aggregate questionnaires and analyze usage status.
    3.Change of purpose of use
    We shall change the purpose of use of personal information only when it is reasonably recognized that the purpose of use is related to that before the change If the purpose of use is changed, the changed purpose shall be announced on this website.
    4.Provision of personal information to a third party
    We will not provide personal information to a third party without the prior consent of the user, except in the following cases. When it is necessary to protect the life, body or property of a person and it is difficult to obtain the consent of the person. When it is particularly necessary to improve public health or promote the sound development of children, and it is difficult to obtain the consent of the person. When it is necessary for a national institution or a local public body or a person entrusted with it to cooperate in carrying out the affairs stipulated by laws and regulations, obtaining the consent of the person will hinder the performance of the affairs. When there is a risk of exerting
    5.Disclosure Of Data
    When requested by the person to disclose personal information, we will disclose it to the person without delay. However, if the disclosure falls under any of the following, we may not disclose all or part of it, and if we decide not to disclose it, we will notify you to that effect without delay. When there is a risk of harming the life, body, property or other rights and interests of the person or a third party When there is a risk of significant hindrance to the proper implementation of our business When it violates other laws and regulations Notwithstanding the provisions of the preceding paragraph, in principle, we will not disclose information other than personal information such as history information and characteristic information.
    6.Correction and deletion of personal information
    If the personal information is incorrect, the user can request us to correct, add or delete the personal information. If we determine that it is necessary to respond to the request from the user, we shall correct the personal information without delay. We will notify the user without delay if we make a correction or if we decide not to make a correction.
    7.Privacy policy changes
    The contents of this policy may be changed without notifying the user, except for laws and regulations and other matters specified otherwise in this policy. The changed privacy policy shall take effect from the time it is posted on this website.
    Contact Us If you have any questions about this Privacy Policy, please contact us:
    By visiting this page on our website: http://www.holonic-systems.com/f-tree/en/index.html#contact






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